Context and Limitations
While the study identifies an association, the authors emphasized that the results do not prove that these products directly cause heart conditions. The analysis relied on voluntary reports from consumers, doctors, and manufacturers, meaning it is unknown how many people consumed the products without adverse effects or how many cardiac events went unreported.
“Although there are biological reasons why that connection could be possible, the study does not prove that caffeine products cause these events, because other factors may have influenced the results found in this analysis,” said Gregory M. Marcus, M.D., M.A.S., FAHA, who was not involved in the study.
Sales of caffeinated energy drinks reached over $20 billion in 2024. While a 2026 American Heart Association Scientific Statement notes that consuming up to 400 mg of caffeine per day is generally safe for most adults, some energy drinks contain up to 3 times more caffeine per fluid ounce than brewed coffee, and some pre-workout supplements contain more than 12 times as much.