Research Limitations
Study author Sai Samayamanthula, a medical student at the University of Virginia School of Medicine, noted that while regular consumption may lead individuals to exceed recommended daily caffeine limits, "the study does not prove that caffeine products cause these events, because other factors may have influenced the results found in this analysis," according to Gregory M. Marcus, M.D., M.A.S., FAHA, who was not involved in the study.
Researchers emphasized that the analysis design only identified associations within voluntarily self-reported data. Because these products are regulated as foods or dietary supplements rather than medications, they do not undergo the same premarket safety testing required for medications.